Mugguru Mongallu is a comedy thriller and Srinivasa Reddy is the biggest highlight of the film. It's the story of Three people who are apparently deaf (Srinivas Reddy), dumb (Deekshit Shetty), and blind (Vennela Rama Rao) each, go to the police station with a few clues regarding the murders. Will the police catch the killers?

Khalindra, a wealthy businessman takes care of his two brothers, after their parents' are murdered. Later, the brothers seek revenge for their parents' death. Will the trio succeed in their mission?